Home Top 10 Series Top 10 Artificial Intelligence Startups in the US

Top 10 Artificial Intelligence Startups in the US

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The artificial intelligence sector of the world today is not easy to quantify. This is owing to the lack of consensus on a unanimous definition for “artificial intelligence” as a term. The growth of startups in this industry has been however extraordinary and its areas of application, limitless. Estimated to contribute an amount of US $15.7 trillion funding to the global economy by 2030, AI is proving to be the future of the world as foretold by many industry experts. Currently servicing top industries in the world, AI shows no limit in its application whatsoever. Some of these industries include healthcare, manufacturing, finance, transportation, media, telecommunication, retail and agriculture to mention a few.

The projected development of the sector has raised a substantial number of startups and caused them to choose artificial intelligence as their primary field of focus. In about 24,531 AI startups globally (2020), we bring you 10 of the biggest and most impactful artificial intelligence startups in one of the largest economies of the world, the United States of America.

  • Argo AI

Argo AI is a startup that provides a technology platform devoted to autonomous navigation of vehicles. The company works closely with world-leading automakers in order to deliver a fully integrated self driving system that can be produced at scale for reliable and safe deployment in goods delivery services and ride sharing.


Founders: Bryan Salesky and Peter Rander

Date of Incorporation: 2016

Headquarters: Pittsburgh, Pennsylvania, United States

Funding Amount: US $3.6 Billion

Number of Investors: 2

Funding Status: Corporate Round

  • UiPath Inc

UiPath is an AI-powered, data-centric startup that specializes in the development of robotics process automation software. The startup offers enhanced control, foolproof development tools, robust governance, automation of complex processes, multiple robots on a single virtual machine and cloud & on-premise deployment. UiPath also provides a studio that models automation visually, a robot that executes processes and an orchestrator that manages critical enterprise duties. 

The startup has offices in key areas of the world including London in the UK, Tokyo in Japan, Bengaluru in India, Melbourne in Australia, Paris in France and Bucharest in Romania. They also provide their services to top industries such as insurance, healthcare, telecom, manufacturing, finance and more.


Founders: Daniel Dines and Marius Tirca

Date of Incorporation: 2005

Headquarters: New York, United States

Funding Amount: US $1.2 Billion

Number of Investors: 26

Funding Status: Secondary Market

  • Tempus, Inc.

Tempus is an AI startup dedicated to improving and advancing the healthcare industry. The company advances precision medicine through the practical application of AI in medical processes. Possessing one of the world’s biggest libraries containing molecular and clinical data, Tempus enables medical practitioners to make data-inspired, real-time decisions to deliver personalized patient care as well as the development and delivery of fully optimized therapeutics. 

The startup utilizes an operating system to make data accessible and useful. Their mission is to ensure that each patient benefits from the treatment of others before them by providing the medical community with instruments that learn as more data is gathered.


Founder: Eric Lefkofsky

Date of Incorporation: 2015

Headquarters: Chicago, Illinois, United States

Funding Amount: US $1.1 Billion

Number of Investors: 10

Funding Status: Debt Financing

  • OpenAI Inc

OpenAI is an AI-driven, non-profit research organization co-founded by the recently established richest man in the world, Elon Musk. The startup aims to delicately develop and promote friendly AI that benefits humanity as opposed to causing harm (as perceived by some). OpenAI plans to collaborate with other organizations and researchers by making its data and patents open to the public. Although the company has raised a substantial amount of funds over the years, they are expected to spend only a tiny fraction of that in the first few years. The founders are partially concerned about the empirical risks associated with artificial intelligence but they are overall not deterred in their mission to aiding humanity using AI systems. 


Founders: Elon Musk, Greg Brockman, Ilya Sutskever, Sam Altman and Wojciech Zaremba

Date of Incorporation: December 11, 2015

Headquarters: San Francisco, California, United States

Funding Amount: US $1 Billion

Number of Investors: 3

Funding Status: Corporate Round

  • Pony.AI, Inc.

Pony.ai is an AI-centric startup that specializes in the development of full-stack autonomous driving solutions. The startup is fully devoted to providing independent mobility everywhere. They achieved this by building the most reliable and safest self-driving technology. Backed by prominent industry investors including Sequoia Capital China, IDG Capital and Legend Capital to mention a few, Pony.ai is currently testing its self driving technology in regions across US and China. 


Founders: James Peng and Tiancheng Lou

Date of Incorporation: December 2016

Headquarters: Fremont, California, United States

Funding Amount: US $993 Million

Number of Investors: 25

Funding Status: Series Unknown

  • Zymergen, Inc.

Zymergen is a biotechnology startup specializing in artificial intelligence, machine learning and big data. The startup collaborates with nature to ensure the development of products and materials across a wide range of industries like electronics, agriculture, pharmaceuticals, consumer care and many more.  


Founders: Jed Dean, Joshua Hoffman and Zach Serber

Date of Incorporation: 2013

Headquarters: Emeryville, California, United States

Funding Amount: US $874.1 Million

Number of Investors: 27

Funding Status: Series D

  • Automation Anywhere, Inc

Automation Anywhere is a business-grade; logical Robotic Process Automation (RPA) startup that empowers users to automate end-to-end business processes using software bots. These bots are digital workers that take care of tedious and monotonous duties thereby resulting in improved productivity, increased customer satisfaction and enhanced efficiency of operations. Automation Anywhere combines RPA, machine learning, AI and analytics to aid the process automation system of organizations. 

With a global network of about 2000 partners and offices in more than 40 countries, the startup is a world leader in AI and RPA. They have deployed more than 1.8 million bots to service about 4000 customers in over 90 countries and across every industry.


Founders: Ankur Kothari, Mihir Shukla, Neeti Mehta and Rushabh Parmani

Date of Incorporation: 2003

Headquarters: San Jose, California, United States

Funding Amount: US $840 Million

Number of Investors: 8

Funding Status: Secondary Market

  • DataRobot, Inc.

DataRobot delivers AI technology and ROI enablement services to enterprises globally. The startup seeks to service organizations competing in today’s intelligence revolution. Their AI platform makes data science publicly available with end-to-end automation aimed at establishing, deploying and managing machine learning models. 


Founders: Jeremy Achin and Thomas DeGodoy

Date of Incorporation: June 1, 2012

Headquarters: Boston, Massachusetts, United States

Funding Amount: US $750.6 Million

Number of Investors: 33

Funding Status: Series F

  • ThoughtSpot, Inc.

ThoughtSpot is a big data analytics and business intelligence startup that aids the analysis, exploration and distribution of real-time business analytics data conveniently. The startup gives every entrepreneur the capacity of a thousand analysts with the aid of their AI-driven framework. A search can be easily carried out and trusted insights, easily gotten with the use of ThoughtSpot. 

The enterprise boasts of many prominent users including Chevron Federal Credit Union, Capital One, Celebrity Cruises, Scotiabank, BT, Amway and De Beers among others. The company was co-founded by Ajeet Singh and six other technical personnel from Microsoft, Oracle, Google and Amazon. Based in Palo Alto, the startup is on the fast track to expansion in regions like North America, Asia-Pacific and Europe.


Founders: Abhishek Rai, Ajeet Singh, Amit Prakash, Priyendra Deshwal, Sanjay Agrawal, Shashank Gupta and Vijay Ganesan

Date of Incorporation: June 1, 2012

Headquarters: Sunnyvale, California, United States

Funding Amount: US $743.7 Million

Number of Investors: 17

Funding Status: Series E

  • Sentinel Labs Inc.

SentinelOne is an AI-powered startup providing autonomous endpoint protection that detects, prevents and guards against attacks across all major vectors. The startup is devoted to providing a solid future for endpoint security with the use of an integrated platform that combines forensics, advanced mitigation and behavioral-based detection to curb threats in real-time.

SentinelOne specializes in attacks that utilize complex and refined evasion strategies. They therefore offer absolute protection from insider-based attacks, malware and exploits of all sorts. SentinelOne was named as the fastest growing startup in Silicon Valley and the seventh fastest growing company in North America as of 2019. The startup has proven to be a world-class threat-detecting platform and as such is able to make the list of the top 10 AI firms in the US.


Founders: Almog Cohen, Ehud Shamir and Tomer Weingarten

Date of Incorporation: 2013

Headquarters: Mountain View, California, United States

Funding Amount: US $696.5 Million

Number of Investors: 17

Funding Status: Series F

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